Aromatic Oligoamide Foldamers with a 'Wet Edge' as Inhibitors of the α-Helix-Mediated p53- hDM2 Protein-Protein Interaction.

This paper describes the design, synthesis and structural analysis of a 3- O-alkylated aromatic oligoamide that incorporates an additional hydrophilic 6- O-alkyl substituent in the central monomer. This oligomer exhibits low μ M inhibitory potency against the p53- hDM2 interaction compared with its unfunctionalised counterpart and significantly improved solubility. [ABSTRACT FROM AUTHOR]