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Biodegradable β-tricalcium phosphate cement with anti-washout property based on chelate-setting mechanism of inositol phosphate.
- Source :
- Journal of Materials Science: Materials in Medicine; Jun2013, Vol. 24 Issue 6, p1383-1394, 12p, 2 Color Photographs, 3 Black and White Photographs, 2 Charts, 4 Graphs
- Publication Year :
- 2013
-
Abstract
- Novel biodegradable β-tricalcium phosphate (β-TCP) cements with anti-washout properties were created on the basis of chelate-setting mechanism of inositol phosphate (IP6) using β-TCP powders. The β-TCP powders were ball-milled using ZrO beads for 0-6 h in the IP6 solutions with concentrations from 0 to 10,000 ppm. The chelate-setting β-TCP cement with anti-washout property was successfully fabricated by mixing the β-TCP powder ball-milled in 3,000 ppm IP6 solution for 3 h and 2.5 mass% NaHPO solution, and compressive strength of the cement was 13.4 ± 0.8 MPa. An in vivo study revealed that the above cement was directly in contact with host and newly formed bones without fibrous tissue layers, and was resorbed by osteoclast-like cells on the surface of the cement. The chelate-setting β-TCP cement with anti-washout property is promising for application as a novel injectable artificial bone with both biodegradability and osteoconductivity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09574530
- Volume :
- 24
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Journal of Materials Science: Materials in Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 87969789
- Full Text :
- https://doi.org/10.1007/s10856-013-4903-8