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Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility.
- Source :
- Nature Genetics; Nov2001, Vol. 29 Issue 3, p261, 2p
- Publication Year :
- 2001
-
Abstract
- Human mitochondrial DNA polymerase, encoded by POLG, contains a polyglutamine tract encoded by a CAG microsatellite repeat. Analysis of POLG genotypes in different populations identified an association between absence of the common, tenrepeat allele and male infertility typified by a range of sperm quality defects but excluding azoospermia. [ABSTRACT FROM AUTHOR]
- Subjects :
- MITOCHONDRIAL DNA
DNA polymerases
MICROSATELLITE repeats
Subjects
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 29
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Nature Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 8781783
- Full Text :
- https://doi.org/10.1038/ng759