Protecting-group-free palladium-catalyzed hydroxylation, C-O and C-N coupling of chiral 6-bromo- and 6,6'-dibromo- 1,1'-binaphthols.

A straightforward, protecting-group-free protocol for the synthesis of chiral 6-substituted and 6,6'-disubstituted binols (binol = 1,1'-bi-2-naphthol) by palladium-catalyzed hydroxylation, C-N and C-O coupling of chiral 6-bromo- and 6,6' -dibromo-1,1'-binaphthols is developed. The protecting group free palladium-catalyzed hydroxylation, C-O and C-N cross-coupling protocol affords a straightforward and general method for the synthesis of chiral 6-substituted and 6,6'-disubstituted binols with good yields, avoiding the tedious procedures of introduction and removal of protecting groups. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]