REVIEWING OF MELOXICAM CONCENTRATION APPLICATED PERORALY AND BY ELECTROPHORESIS ON INJURIED KNEE ANKLE OF PARACHUTISTS.

The research goal was to qualify concentration of meloxicam (M), applied oral and by electrophoresis (EF) in meniscus and synovial liquid of the damaged knee ankle, because of sport injuries within the parachutists. Research sample included 8 sport male parachutists, age 28-48, divided into 2 groups with 4 examinees each. For the first group 0,015 g M, was per oral (1 tablet per day) applied during 5 days, and the second group of 4 parachutists for same drug dosage equally by electrophoresis (EF). Meniscus and synovial liquid samples were taken afterwards by menisectomy. By methods of liquid-mass spectrometry (HPCL) the drug concentration was quantified in micrograms of medicament per g of tissue, applied within the both ways. The research results were tested by Student t-test for small pairs of samples, and high significant concentration of drug was noted p<0,001, applied in one term EF in meniscus and synovial liquid in comparison to five day per oral drug application. By Eliminating, the local applied systems effects, and maximal concentration of drug, by longer maintaining in the targeted tissue, EF can be recommended as a method of choice in clinical praxis for sport injuries. Electrophoresis application of Meloxicam in targeting the knee joint provides significant saturation and better effectiveness of the drug compared to the per oral application [ABSTRACT FROM AUTHOR]