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Interleukin receptor family member ST2 concentrations in patients following heart transplantation.

Authors :
Januzzi, James L.
Horne, Benjamin D.
Moore, Stephanie A.
Galenko, Oxana
Snow, Gregory L.
Brunisholz, Kimberly D.
Muhlestein, Joseph B.
Alharethi, Rami
Carlquist, John F.
Budge, Deborah
Rasmussen, Kismet
Kfoury, Abdallah G.
Source :
Biomarkers; May2013, Vol. 18 Issue 3, p250-256, 7p
Publication Year :
2013

Abstract

Objective: To evaluate soluble (s) ST2 as a biomarker of rejection, allograft vasculopathy and mortality after orthotopic heart transplantation (OHT). Methods: sST2 concentrations were measured in 241 patients following OHT. Results: Elevated sST2 was associated with cellular rejection (CR) ≥1R, with highest rates of CR in the 4th sST2 quartile ( p = 0.003). No significant association between sST2 and antibody-mediated rejection or allograft vasculopathy was found. sST2 ≥30 ng/mL independently predicted death over 7-year follow-up (HR = 2.01; 95% CI 1.15-3.51; p = 0.01). Conclusion: Concentrations of sST2 are associated with the presence of CR and predict long-term mortality following OHT. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1354750X
Volume :
18
Issue :
3
Database :
Complementary Index
Journal :
Biomarkers
Publication Type :
Academic Journal
Accession number :
87095912
Full Text :
https://doi.org/10.3109/1354750X.2013.773081