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Interleukin receptor family member ST2 concentrations in patients following heart transplantation.
- Source :
- Biomarkers; May2013, Vol. 18 Issue 3, p250-256, 7p
- Publication Year :
- 2013
-
Abstract
- Objective: To evaluate soluble (s) ST2 as a biomarker of rejection, allograft vasculopathy and mortality after orthotopic heart transplantation (OHT). Methods: sST2 concentrations were measured in 241 patients following OHT. Results: Elevated sST2 was associated with cellular rejection (CR) ≥1R, with highest rates of CR in the 4th sST2 quartile ( p = 0.003). No significant association between sST2 and antibody-mediated rejection or allograft vasculopathy was found. sST2 ≥30 ng/mL independently predicted death over 7-year follow-up (HR = 2.01; 95% CI 1.15-3.51; p = 0.01). Conclusion: Concentrations of sST2 are associated with the presence of CR and predict long-term mortality following OHT. [ABSTRACT FROM AUTHOR]
- Subjects :
- HEART transplantation
INTERLEUKIN receptors
BIOMARKERS
HOMOGRAFTS
IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 1354750X
- Volume :
- 18
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 87095912
- Full Text :
- https://doi.org/10.3109/1354750X.2013.773081