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Environmental pH-responsive fluorescent PEG-polyurethane for potential optical imaging.
- Source :
- Journal of Applied Polymer Science; Jul2013, Vol. 129 Issue 2, p846-852, 7p
- Publication Year :
- 2013
-
Abstract
- A series of environmental pH-responsive block copolymers PEG-polyurethane with tertiary amine groups in the main chain and free carboxyl groups in the side chain were synthesized, including poly(ethylene glycol) (PEG), 1,4-bis (hydroxyethyl) piperazine, 1,6-diisocyanato hexamethylene, and 2,2-dimethylolpropionic acid. The chemical structure, molecular weight, and pH-dependent capacity of pH-responsive PEG-polyurethane were examined by <superscript>1</superscript>H-NMR, FTIR, gel permeation chromatography (GPC), and an acid-base titration. Moreover, the fluorescent dye fluorescein isothiocyanate was conjugated with PEG-polyurethane by the similar polymerization method and the obtained polymer was measured by ultraviolet visible spectroscopy (UV-vis) and fluorescent spectroscopy. The results indicated that the pH-responsive PEG-polyurethane showed a pH-buffering phenomenon and fluorescent imaging in a range of pH values. As a result, we demonstrated its potential application for optical imaging; however, it is believed that more applications in the areas of biomedicine will be possible owing to its free carboxyl acid terminal residues in the stimuli-responsive polymer. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00218995
- Volume :
- 129
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Applied Polymer Science
- Publication Type :
- Academic Journal
- Accession number :
- 87042747
- Full Text :
- https://doi.org/10.1002/app.38880