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A new phenanthrene derivative and two diarylheptanoids from the roots of Brassica rapa ssp . campestris inhibit the growth of cancer cell lines and LDL-oxidation.
- Source :
- Archives of Pharmacal Research; Apr2013, Vol. 36 Issue 4, p423-429, 7p
- Publication Year :
- 2013
-
Abstract
- Brassica rapa ssp. campestris (Brassicaceae) is a conical, deep purple, edible root vegetable commonly known as a turnip. We initiated phytochemical and pharmacological studies to search for biological active compounds from the roots of B. rapa ssp. campestris. We isolated a novel phenanthrene derivative, 6-methoxy-1-[10-methoxy-7-(3-methylbut-2-enyl)phenanthren-3-yl]undecane-2,4-dione, named brassicaphenanthrene A ( 3) along with two known diarylheptanoid compounds, 6-paradol ( 1) and trans-6-shogaol ( 2), through the repeated silica gel (SiO), octadecyl silica gel, and Sephadex LH-20 column chromatography. The chemical structures of the compounds were determined by spectroscopic data analyses including nuclear magnetic resonance, mass spectrometry, ultraviolet spectroscopy, and infra-red spectroscopy. All compounds exhibited high inhibitory activity against the growth of human cancer lines, HCT-116, MCF-7, and HeLa, with IC values ranging from 15.0 to 35.0 μM and against LDL-oxidation with IC values ranging from 2.9 to 7.1 μM. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02536269
- Volume :
- 36
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Archives of Pharmacal Research
- Publication Type :
- Academic Journal
- Accession number :
- 87015687
- Full Text :
- https://doi.org/10.1007/s12272-013-0068-8