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Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300.
- Source :
- BMC Genomics; 2012, Vol. 13 Issue 1, p1-11, 11p, 1 Diagram, 3 Charts, 1 Graph
- Publication Year :
- 2012
-
Abstract
- Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is a significant bacterial pathogen that poses considerable clinical and public health challenges. The majority of the CA-MRSA disease burden consists of skin and soft tissue infections (SSTI) not associated with significant morbidity; however, CA-MRSA also causes severe, invasive infections resulting in significant morbidity and mortality. The broad range of disease severity may be influenced by bacterial genetic variation. Results: We sequenced the complete genomes of 36 CA-MRSA clinical isolates from the predominant North American community acquired clonal type USA300 (18 SSTI and 18 severe infection-associated isolates). While all 36 isolates shared remarkable genetic similarity, we found greater overall time-dependent sequence diversity among SSTI isolates. In addition, pathway analysis of non-synonymous variations revealed increased sequence diversity in the putative virulence genes of SSTI isolates. Conclusions: Here we report the first whole genome survey of diverse clinical isolates of the USA300 lineage and describe the evolution of the pathogen over time within a defined geographic area. The results demonstrate the close relatedness of clinically independent CA-MRSA isolates, which carry implications for understanding CA-MRSA epidemiology and combating its spread. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14712164
- Volume :
- 13
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 86883388
- Full Text :
- https://doi.org/10.1186/1471-2164-13-508