'Stroke-like syndrome' caused by intrathecal methotrexate in patients treated during the UKALL 2003 trial.

This article discusses research on the clinical spectrum of intrathecal methotrexate (IT MTX)-related stroke-like syndrome (SLS) in patients with acute lymphoblastic leukaemia (ALL) who were treated during the Medical Research Council UKALL 2003 trial in Great Britain. Researchers reviewed 203 investigator-generated reports of neurological serious adverse effects associated with IT MTX administration and learned that 31 cases are consistent with an SLS-type presentation.