Antitumor Effects of Typhonium giganteum Engl, Tuber Extracts.

Aim: To study the antitumor activities of 70% ethanol extracts of Typhonium giganteum Engl. tuber in human Liver Cancer Bel-7402 and Lung Cancer A549 Cell Lines in vitro. Method: Bel-7402 and A549 cells proliferative activities were measured by MTT method in vitro. Cells apoptosis were analyzed by morphology analysis. Results: Bel-7402 and A549 cells were treated with of Typhonium giganteum Engl. tuber extracts (TGE) at concentrations from 1.0, 10.0 to 100.0 mg•L-1 for 24 to 72 h, cellular proliferation were inhibited with the increase of concentration and time. Compared with the control group, the significant apoptotic morphology changes were observed. Conclusion: 70% ethanol extracts of Typhonium giganteum Engl. tuber can decrease the proliferation rate and induce apoptosis of Bel-7402 and A549 cells. Taken together, these results suggested that Typhonium giganteum Engl. was a promising herbal drug in the therapy of human Liver Cancer and Lung Cancer. [ABSTRACT FROM PUBLISHER]