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P21 Gene Variation and Late-Onset Alzheimer's Disease in the Italian Population.
- Source :
- Dementia & Geriatric Cognitive Disorders; Feb2013, Vol. 35 Issue 1/2, p51-57, 7p, 2 Charts
- Publication Year :
- 2013
-
Abstract
- Background: Variation at the cyclin-dependent kinase inhibitor gene P21 in a patient sample of the Italian population was investigated in search of genetic factors potentially involved in sporadic late-onset Alzheimer's disease (AD). Methods: Two single nucleotide polymorphisms (SNPs) were studied in this gene: a C>A transversion at codon 31 (ser>arg) in exon 2 (RS1801270) and a C>T transition occurring 20 bp downstream from the stop codon of exon 3 (RS1059234). Results: The odd ratios were: RS1801270 A allele = 0.62 (95% CI = 0.33-1.18; p = 0.14); RS1059234 T allele = 0.57 (95% CI = 0.33-0.98; p = 0.04). In addition, a longer duration of disease was found with genotypes carrying the RS1059234 T allele (4.3 ± 2.5 years) than with those not carrying it (3.3 ± 2.1 years) (p = 0.001). Conclusion: In the present sample, one of the two SNPs seems in some way related to AD, since carriers of one allele were slightly protected against AD onset. Copyright © 2013 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- GENETICS of Alzheimer's disease
AGE factors in disease
ALLELES
ANALYSIS of variance
BLOOD testing
CHI-squared test
COMPARATIVE studies
CONFIDENCE intervals
EPIDEMIOLOGY
GENES
GENETIC polymorphisms
GENETIC techniques
NEUROPSYCHOLOGICAL tests
POPULATION geography
PROTEIN kinases
RESEARCH funding
LOGISTIC regression analysis
DATA analysis
CONTROL groups
DISEASE duration
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 14208008
- Volume :
- 35
- Issue :
- 1/2
- Database :
- Complementary Index
- Journal :
- Dementia & Geriatric Cognitive Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 86365916
- Full Text :
- https://doi.org/10.1159/000345788