Back to Search
Start Over
Novel synthesis of telithromycin.
- Source :
- Journal of Chemical Research; Feb2013, Vol. 37 Issue 2, p107-109, 3p, 2 Diagrams
- Publication Year :
- 2013
-
Abstract
- A novel synthesis route for telithromycin was developed based on a 11,12-cylic carbonate protection strategy to prevent formation of 9,12-hemiacetal by-product. Through a 11,12-carbonate-6-O-methylerythromycin intermediate, telithromycin was synthesised from 6-O-methylerythromycin in five steps with 33% overall yield. [ABSTRACT FROM AUTHOR]
- Subjects :
- TELITHROMYCIN
CARBONATES
ERYTHROMYCIN
METHYL ether synthesis
CHEMICAL synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 17475198
- Volume :
- 37
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Chemical Research
- Publication Type :
- Academic Journal
- Accession number :
- 86141144
- Full Text :
- https://doi.org/10.3184/174751913X13574995608294