Synthesis of Phospholipid Ribavirin Conjugates.

New conjugates of antiviral nucleoside Ribavirin (=1-( β- D-ribofuranosyl)-1 H-1,2,4-triazole-3-carboxamide; 1) with 1,2- and 1,3-diacyl glycerophosphates have been synthesized by the phosphoramidite method. A combination of 2′,3′-phenylboronate protecting group for the sugar moiety of the ribonucleoside 1 and 2-cyanoethyl protection for the phosphate fragment ensured the preparation of the desired compounds with reasonable yields via a small number of synthetic steps. [ABSTRACT FROM AUTHOR]