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18F-Fluorodeoxyglucose positron emission tomography/computed tomography for the detection of recurrent bone and soft tissue sarcoma.
- Source :
- Cancer (0008543X); Mar2013, Vol. 119 Issue 6, p1227-1234, 8p
- Publication Year :
- 2013
-
Abstract
- BACKGROUND: The clinical utility of modern hybrid imaging modalities for detecting recurrent bone or soft tissue sarcoma remains to be determined. In this report, the authors present a clinical study on the diagnostic accuracy and incremental value of integrated <superscript>18</superscript>F-fluorodeoxyglucose positron emission tomography/computed tomography (<superscript>18</superscript>F-FDG PET/CT) in patients with a history of sarcoma who have clinically suspected disease recurrence. METHODS: Forty-three patients who had a history of bone or soft tissue sarcoma and had documented complete remission underwent <superscript>18</superscript>F-FDG PET/CT. Image analysis was performed independently for <superscript>18</superscript>F-FDG PET (n = 43) and for contrast-enhanced spiral CT (CE-CT) (n = 30) by 2 separate readers, whereas combined <superscript>18</superscript>F-FDG PET/CT (n = 43) images were analyzed in consensus by both readers. Imaging findings were rated on a 5-point scale and finally were reported as malignant, benign, or equivocal. Imaging findings were validated either by histopathology (n = 24) or by clinical follow-up (n = 19). RESULTS: <superscript>18</superscript>F-FDG PET/CT had greater sensitivity and specificity compared with CE-CT alone (94% and 92% vs 78% and 67%, respectively), resulting in significantly greater accuracy (93% vs 73%; P = .03). <superscript>18</superscript>F-FDG PET/CT was particularly superior regarding detection of local recurrence or soft tissue lesions (sensitivity and specificity: 83% and 100% vs 50% and 100%, respectively) or bone metastases (100% and 100% vs 85% and 88%, respectively). CONCLUSIONS: <superscript>18</superscript>F-FDG PET/CT had greater diagnostic accuracy in the detection of recurrent bone or soft tissue sarcoma compared with CE-CT alone. The detection of local recurrence was the most evident advantage of <superscript>18</superscript>F-FDG PET/CT over CE-CT. Cancer 2013. © 2012 American Cancer Society. [ABSTRACT FROM AUTHOR]
- Subjects :
- SOFT tissue tumors
SARCOMA
OSTEOSARCOMA
BONE tumors
BONE metastasis
Subjects
Details
- Language :
- English
- ISSN :
- 0008543X
- Volume :
- 119
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Cancer (0008543X)
- Publication Type :
- Academic Journal
- Accession number :
- 85871965
- Full Text :
- https://doi.org/10.1002/cncr.27866