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Diabetes Genetic Predisposition Score and Cardiovascular Complications Among Patients With Type 2 Diabetes.
- Source :
- Diabetes Care; Mar2013, Vol. 36 Issue 3, p737-739, 3p, 1 Chart
- Publication Year :
- 2013
-
Abstract
- OBJECTIVE -- To examine the association between genetic predisposition to type 2 diabetes (T2D) and risk of cardiovascular disease (CVD) among patients with T2D. RESEARCH DESIGN AND METHODS -- The current study included 1,012 men and 1,310 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, including 677 patients with CVD and 1,645 non-CVD control subjects. A genetic predisposition score (GPS) was calculated on the basis of 36 established independent diabetes-predisposing variants. RESULTS -- Each additional diabetes-risk allele in the GPS was associated with a 3% increased risk of CVD (odds ratio [OR] 1.03 [95% CI 1.00-1.06]). The OR was 1.47 (1.11-1.95) for CVD risk by comparing extreme quartiles of the GPS (P for trend = 0.01). We also found that the GPS was positively associated with hemoglobin A<subscript>1c</subscript> levels (P = 0.009). CONCLUSIONS -- Genetic predisposition to T2D is associated with an increased risk of cardiovascular complications in patients with T2D. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01495992
- Volume :
- 36
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Diabetes Care
- Publication Type :
- Academic Journal
- Accession number :
- 85782200
- Full Text :
- https://doi.org/10.2337/dc12-0852