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Target Identification: A Challenging Step in Forward Chemical Genetics.
- Source :
- Interdisciplinary Bio Central; 2011, Issue 3, Special section p1-16, 16p
- Publication Year :
- 2011
-
Abstract
- Investigation of the genetic functions in complex biological systems is a challenging step in recent year. Hence, several valuable and interesting research projects have been developed with novel ideas to find out the unknown functions of genes or proteins. To validate the applicability of their novel ideas, various approaches are built up. To date, the most promising and commonly used approach for discovering the target proteins from biological system using small molecule is well known a forward chemical genetics which is considered to be more convenient than the classical genetics. Although, the forward chemical genetics consists of the three basic components, the target identification is the most challenging step to chemical biology researchers. Hence, the diverse target identification methods have been developed and adopted to disclose the small molecule bound protein. Herein, in this review, we briefly described the first two parts chemical toolbox and screening, and then the target identifications in forward chemical genetics are thoroughly described along with the illustrative real example case study. In the tabular form, the different biological active small molecules which are the successful examples of target identifications are accounted in this research review. [ABSTRACT FROM AUTHOR]
- Subjects :
- BIOCHEMICAL genetics
MOLECULES
PHENOTYPES
BIOCHEMISTRY
MOLECULAR genetics
Subjects
Details
- Language :
- English
- ISSN :
- 20058543
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Interdisciplinary Bio Central
- Publication Type :
- Academic Journal
- Accession number :
- 85628287
- Full Text :
- https://doi.org/10.4051/ibc.2011.3.1.0003