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A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis.
- Source :
- Journal of Clinical Periodontology; Mar2013, Vol. 40 Issue 3, p227-241, 15p, 1 Black and White Photograph, 1 Diagram, 8 Charts
- Publication Year :
- 2013
-
Abstract
- Aims To update the existing scientific evidence on the efficacy of local antimicrobials as adjuncts to subgingival debridement in the treatment of chronic periodontitis. Material and Methods Fifty-six papers were selected, reporting data from 52 different investigations. All the studies reported changes in probing pocket depth ( PPD) and clinical attachment level ( CAL) and most in plaque index (PlI) and/or bleeding on probing ( BOP). Meta-analyses were performed with the data retrieved from the studies fulfilling the inclusion criteria. Results The overall effect of the subgingival application of antimicrobials was statistically significant ( p = 0.000) for both changes in PPD and CAL with a weighted mean difference ( WMD) of −0.407 and −0.310 mm respectively. No significant differences occurred for changes in BOP and PlI. Subgingival application of tetracycline fibres, sustained released doxycycline and minocycline demonstrated a significant benefit in PPD reduction ( WMD between 0.5 and 0.7 mm). The rest of the tested outcomes demonstrated a high heterogeneity. The local application of chlorhexidine and metronidazole showed a minimal effect when compared with placebo ( WMD between 0.1 and 0.4 mm). Conclusions The scientific evidence supports the adjunctive use of local antimicrobials to debridement in deep or recurrent periodontal sites, mostly when using vehicles with proven sustained release of the antimicrobial. [ABSTRACT FROM AUTHOR]
- Subjects :
- DEBRIDEMENT
PERIODONTITIS treatment
ANTIBIOTICS
ACADEMIC medical centers
ANALYSIS of variance
CHI-squared test
COMBINED modality therapy
CONFIDENCE intervals
DENTAL scaling
INFORMATION storage & retrieval systems
MEDICAL databases
MEDICAL information storage & retrieval systems
MEDLINE
META-analysis
ONLINE information services
RESEARCH funding
TOOTH root planing
RANDOMIZED controlled trials
DATA analysis software
ADVERSE health care events
Subjects
Details
- Language :
- English
- ISSN :
- 03036979
- Volume :
- 40
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 85293371
- Full Text :
- https://doi.org/10.1111/jcpe.12026