CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.

The article discusses a study on role of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) in the thymic development of conventional and regulatory T cells (Tconv and Treg). It examines the mechanism of the immunological process of central tolerance in the thymus, such as the selection of T-cell receptor (TCR) and negative selection. It states that the location of CTLA-4 in the corticomedullary region in mice suggests that it influences thymic development of Tconv and Treg cells.