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Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity.
- Source :
- Biomarkers; Feb2013, Vol. 18 Issue 1, p73-81, 9p
- Publication Year :
- 2013
-
Abstract
- Objective: To investigate whether lipid and protein oxidation products are elevated and correlated with routine clinical markers of hepatic and renal function in patients anesthetized with halothane, isoflurane, or sevoflurane. Methods: Urine and blood samples were collected from patient groups. Excretion of aldehydes, acetone, and o,o'-dityrosine was measured before and after anesthesia. Blood samples were analysed for clinical markers. Results: Urinary concentrations of aldehydes, acetone, o,o'-dityrosine and glucose were significantly increased after anesthesia in halothane and sevoflurane groups earlier than clinical markers. Significant correlations were found in sevoflurane group. Conclusion: Lipid and protein oxidation contributes to subclinical sevoflurane nephrotoxicity. Oxidation products may serve as early biomarkers. [ABSTRACT FROM AUTHOR]
- Subjects :
- OXIDATION
LIPIDS
NEPHROTOXICOLOGY
ALDEHYDES
ACETONE
HALOTHANE
BIOMARKERS
Subjects
Details
- Language :
- English
- ISSN :
- 1354750X
- Volume :
- 18
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 84944961
- Full Text :
- https://doi.org/10.3109/1354750X.2012.737026