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Intravenous iron supplementation for the treatment of chemotherapy-induced anaemia - systematic review and meta-analysis of randomised controlled trials.
- Source :
- Acta Oncologica; Jan2013, Vol. 52 Issue 1, p18-29, 12p, 1 Illustration, 5 Charts, 1 Graph
- Publication Year :
- 2013
-
Abstract
- Background: Current guidelines are inconclusive regarding intravenous (IV) iron for treatment of chemotherapy-induced anaemia (CIA). Material and methods: Systematic review and meta-analysis of randomised controlled trials comparing IV iron with no iron or oral iron for treatment of chemotherapy induced anaemia (CIA). Primary outcomes: haematopoietic response and red blood cell (RBC) transfusion requirements. For dichotomous data, relative risks (RR) with 95% confidence intervals (CIs) were estimated and pooled. For continuous data, weighted mean differences were calculated. Results: Eleven trials included 1681 patients, the majority examining the addition of IV iron to erythropoiesis stimulating agents (ESA) (1562 patients, 92.9%). IV iron significantly increased haematopoietic response rate [RR 1.28 (95% CI 1.125-1.45), seven trials with ESA] and decreased the rate of blood transfusions both in trials with ESA [RR 0.76 (95% CI 0.61-0.95), seven trials] and without ESA [RR 0.52 (95% CI 0.34-0.80)]. The increase in haematopoietic response rate correlated with total IV iron dose, regardless of baseline iron status. Mortality and safety profile was comparable between groups. Conclusions: IV iron added to ESA results in an increase in haematopoietic response and reduction in the need for RBC transfusions, with no difference in mortality or adverse events. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANEMIA
CANCER chemotherapy
CANCER patients
CHI-squared test
CONFIDENCE intervals
DIETARY supplements
INFORMATION storage & retrieval systems
MEDICAL databases
INTRAVENOUS therapy
IRON
MEDLINE
META-analysis
ONLINE information services
REGRESSION analysis
SYSTEMATIC reviews
RANDOMIZED controlled trials
DATA analysis software
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 0284186X
- Volume :
- 52
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Acta Oncologica
- Publication Type :
- Academic Journal
- Accession number :
- 84373813
- Full Text :
- https://doi.org/10.3109/0284186X.2012.702921