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Cadmium and selenium in blood and urine related to smoking habits and previous exposure to mercury vapour
- Source :
- Journal of Applied Toxicology; Sep/Oct1997, Vol. 17 Issue 5, p337, 0p
- Publication Year :
- 1997
-
Abstract
- The object of this work was to investigate possible interactions of mercury, cadmium and selenium in humans. Selenium and cadmium in blood and urine were determined in this cross-sectional study of 130 males, of whom 77 had been previously exposed to mercury vapour at a chloralkali plant. Of the participants, 61.5% were smokers and 16.2% werenever-smokers. The concentration of selenium in blood (B-Se) was significantly lower in subjects currently smoking more than 50 g of tobacco per week compared to never-smokers, whereas the concentration of cadmium in blood (B-Cd) was significantly higher in all categories ofcurrent smokers. In the multiple linear regression analysis, B-Se asa dependent variable was negatively associated with B-Cd, whereas current smoking habits were not included in the model as a predictor variable. In contrast, B-Cd as a dependent variable was positively associated with current as well as previous smoking habits, and negatively with both B-Se and the 'cumulative dose'of previous mercury vapour exposure. The concentration of selenium in blood was also negatively associated with B-Cd in the group of never-smokers (Spearman's r = -0.80; P < 0.001). In conclusion, these results suggest a depressive effect of cadmium on the concentration of selenium in blood, while smoking alone did not operate as a true predictor for this effect. Furthermore, previous exposure to mercury apparently modifies the concentration of cadmium in blood. [ABSTRACT FROM AUTHOR]
- Subjects :
- SMOKING
URINE
TOXICOLOGY
CADMIUM
BLOOD
BIOCHEMISTRY
SELENIUM
TOXIC substance exposure
Subjects
Details
- Language :
- English
- ISSN :
- 0260437X
- Volume :
- 17
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Applied Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 8435559