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How do CARs work? Early insights from recent clinical studies targeting CD19.
- Source :
- OncoImmunology; Dec2012, Vol. 1 Issue 9, p1-7, 7p
- Publication Year :
- 2012
-
Abstract
- Second-generation chimeric antigen receptors (CARs) are powerful tools to redirect antigen-specific T cells independently of HLA-restriction. Recent clinical studies evaluating CD19- targeted T cells in patients with B-cell malignancies demonstrate the potency of CAR-engineered T cells. With results from 28 subjects enrolled by five centers conducting studies in patients with chronic lymphocytic leukemia (CLL) or lymphoma, some insights into the parameters that determine T-cell function and clinical outcome of CAR-based approaches are emerging. These parameters involve CAR design, T-cell production methods, conditioning chemotherapy as well as patient selection. Here, we discuss the potential relevance of these findings and in particular the interplay between the adoptive transfer of T cells and pre-transfer patient conditioning. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTIGEN receptors
T cells
HLA histocompatibility antigens
B cells
CHIMERIC proteins
Subjects
Details
- Language :
- English
- ISSN :
- 21624011
- Volume :
- 1
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- OncoImmunology
- Publication Type :
- Academic Journal
- Accession number :
- 84197579
- Full Text :
- https://doi.org/10.4161/onci.22524