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The impact of vitamin D on pregnancy: a systematic review.
- Source :
- Acta Obstetricia et Gynecologica Scandinavica; Dec2012, Vol. 91 Issue 12, p1357-1367, 11p
- Publication Year :
- 2012
-
Abstract
- Hypovitaminosis D is common in pregnancy. To systematically review the evidence on vitamin D-dependent pregnancy outcomes, PubMed and Embase were searched for randomized control trials, cohort and case-control studies. In randomized control trials ( n = 7), larger doses of vitamin D resulted in higher 25-hydroxylated vitamin D (25OHD) levels ( n = 6), increased maternal weight gain ( n = 1), and fewer classical vitamin D deficiency symptoms ( n = 1). In observational studies ( n = 32), lower vitamin D intake, or low 25OHD-levels, were associated with adverse fertility parameters ( n = 2), preeclampsia ( n = 5), gestational diabetes or higher blood glucose ( n = 6), bacterial vaginosis ( n = 4), primary cesarean section ( n = 1), none ( n = 3) or a few days' ( n = 2) shorter gestation, and postpartum depression ( n = 1). Studies with few participants having low 25OHD did not identify an association to preeclampsia ( n = 5) or gestational diabetes ( n = 2). Increased odds of pregnancy-associated breast cancer with 25OHD >25.8 nmol/L were observed ( n = 1). In conclusion, an effect of vitamin D on several pregnancy outcomes is suggested. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00016349
- Volume :
- 91
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Acta Obstetricia et Gynecologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 83847156
- Full Text :
- https://doi.org/10.1111/aogs.12000