Involvement of the 5-HT1A and 5-HT2A/2C serotonin receptors in the anxious behavior of prenatally stressed ovariectomized rats.

We compared the effects of an antagonist of 5-HT receptors, NAN-190 (0.1 mg/kg intraperitoneally), and an antagonist of 5-HT receptors, ketanserin (0.1 mg/kg intraperitoneally), which were chronically injected for 14 days, on the anxiety level in prenatally stressed female rats with an ovariectomyinduced experimental deficiency of estrogens. Chronic administration of ketanserin to ovariectomized prenatally stressed females had an anxiolytic effect and corrected disturbed levels of follitropin, lutropin, and estradiol. Administration of NAN-190 to ovariectomized prenatally stressed rats increased the anxiety level and decreased the ratio between the levels of tropic and peripheral sex hormones. [ABSTRACT FROM AUTHOR]