Back to Search
Start Over
Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans.
- Source :
- Nature Chemical Biology; Dec2012, Vol. 8 Issue 12, p960-962, 3p, 3 Graphs
- Publication Year :
- 2012
-
Abstract
- The finding that oxygenase-catalyzed protein hydroxylation regulates animal transcription raises questions as to whether the translation machinery and prokaryotic proteins are analogously modified. Escherichia coli ycfD is a growth-regulating 2-oxoglutarate oxygenase catalyzing arginyl hydroxylation of the ribosomal protein Rpl16. Human ycfD homologs, Myc-induced nuclear antigen (MINA53) and NO66, are also linked to growth and catalyze histidyl hydroxylation of Rpl27a and Rpl8, respectively. This work reveals new therapeutic possibilities via oxygenase inhibition and by targeting modified over unmodified ribosomes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15524450
- Volume :
- 8
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Nature Chemical Biology
- Publication Type :
- Academic Journal
- Accession number :
- 83590749
- Full Text :
- https://doi.org/10.1038/nchembio.1093