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Correlation of pretreatment serum tissue polypeptide specific antigen (TPS) with prognosis in primary breast cancer.
- Source :
- Chinese-German Journal of Clinical Oncology; Nov2012, Vol. 11 Issue 11, p655-659, 5p
- Publication Year :
- 2012
-
Abstract
- Objective: The aim of this study was to explore the correlation of pretreatment serum tissue polypeptide specific antigen (TPS) with prognosis in primary breast cancer. Methods: A total of 361 patients with grades I-III breast cancer had been followed up from January 2001 to February 2011. Serumal TPS level was measured by enzyme-linked immunosorbent assays (ELISA). Univariate and multivariate analyses were used to investigate associations between pretreatment TPS level and clinicopathological parameters and patient outcomes. Results: First, at the univariate analysis, the expression of TPS was related with some clinicopathological traditional prognostic factors such as tumor size ( P = 0.030), histologic grade ( P = 0.001) and lymph node status ( P = 0.008). Second, overall survival were significantly shorter among patients with elevated pretreatment serum TPS ( P = 0.038). However, finally, multivariate Cox regression indicated that the level of pretreatment serum TPS was not an independent prognostic parameter for overall survival in primarily breast cancer patients ( P > 0.05). Conclusion: The expression of pretreatment serum TPS is closely correlated with clinicopathology parameters and overall survival of patients with primarily breast cancer, but its level has no independent prognostic value. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16101979
- Volume :
- 11
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Chinese-German Journal of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 83384270
- Full Text :
- https://doi.org/10.1007/s10330-012-1060-3