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Preventive Effectiveness of Implantable Cardioverter Defibrillator in Reducing Sudden Cardiac Death in the Chinese Population: A Multicenter Trial of ICD Therapy versus Non-ICD Therapy.
- Source :
- Journal of Cardiovascular Electrophysiology; Nov2012 Supplement, Vol. 23, ps5-s9, 5p, 1 Diagram, 4 Charts
- Publication Year :
- 2012
-
Abstract
- Preventive Effectiveness of Implantable Cardioverter. Introduction: This prospective and multicenter trial of the implantable cardioverter-defibrillator (ICD) aimed to evaluate the mortality rate (including sudden cardiac death [SCD]) and the efficacy of ICD in Chinese patients with high risk of sudden death. Methods and Results : This trial was conducted in 31 centers in China. We enrolled 497 patients who fulfilled Class I indication for ICD (2002 ACC/AHA/NASPE guideline). All patients were followed-up at 3, 6, and 12 months. Clinical characteristics and echocardiographic parameters were collected at baseline and follow-up; Kaplan-Meier survival analysis was performed. Among 497 enrolled patients with Class I indication of ICD therapy, 112 (22.5%) agreed to and received ICD implantation (ICD group). The remaining 385 patients who were not available for ICD therapy were designated as the non-ICD group. During a mean follow-up of 11 ± 3 months, there were a total of 38 deaths, 2 in the ICD group with a mortality of 1.8% and 36 in the non-ICD group, with a mortality of 9.4% and 26 due to SCD. The overall survival rate was 93% at 3 months of follow-up, 91% at 6 months, and 89% at 12 months, with an incidence of SCD of 5%, 7%, and 8% at 3, 6, and 12 months, respectively. Conclusions : In patients with Class I indication of ICD implantation, the total mortality and incidence of SCD were high. ICD therapy can effectively reduce the mortality in such patients. (J Cardiovasc Electrophysiol, Vol. 23, pp. S5-S9, November 2012) [ABSTRACT FROM AUTHOR]
- Subjects :
- CARDIAC arrest prevention
IMPLANTABLE cardioverter-defibrillators
ANALYSIS of variance
CARDIAC arrest
CHI-squared test
CHINESE people
LONGITUDINAL method
MEDICAL cooperation
MORTALITY
HEALTH outcome assessment
RESEARCH
T-test (Statistics)
RANDOMIZED controlled trials
TREATMENT effectiveness
DESCRIPTIVE statistics
KAPLAN-Meier estimator
Subjects
Details
- Language :
- English
- ISSN :
- 10453873
- Volume :
- 23
- Database :
- Complementary Index
- Journal :
- Journal of Cardiovascular Electrophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 83327835
- Full Text :
- https://doi.org/10.1111/j.1540-8167.2012.02435.x