Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non- Hodgkin lymphoma subtypes.

A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia ( CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non- Hodgkin lymphoma ( NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10⁻³). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes. [ABSTRACT FROM AUTHOR]