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Electrophoretic Preparation of an Organic-Inorganic Hybrid of Layered Metal Hydroxide and Hydrogel for a Potential Drug-Delivery System.

Authors :
Gwak, Gyeong-Hyeon
Paek, Seung-Min
Oh, Jae-Min
Source :
European Journal of Inorganic Chemistry; Nov2012, Vol. 2012 Issue 32, p5269-5275, 7p
Publication Year :
2012

Abstract

We have prepared organic-inorganic hybrid materials consisting of layered metal hydroxides and hydrogel polymers for potential use as a drug delivery system. The hybrid materials were synthesized by an electrophoretic method; anionic precursors, OH<superscript>-</superscript>/CO<subscript>3</subscript><superscript>2-</superscript>, and cationic metal Zn<superscript>2+</superscript> were migrated into hydrogel by applying an electrical potential of 25 V for 20 min to form inorganic nanocrystals inside the hydrogel matrix. Hydrozincite [Zn<subscript>5</subscript>(OH)<subscript>8</subscript>(CO<subscript>3</subscript>)] nanoparticles, a kind of layered metal hydroxide, were determined to develop inside the hydrogel according to powder X-ray diffraction, FTIR, and X-ray absorption spectroscopy. Scanning electron microscopic images showed that the prepared hybrid materials have well-dispersed inorganic nanoparticles in the hydrogel matrix. In order to evaluate the potential of the thus prepared hybrid materials as a drug-delivery system, the well-known antioxidant ferulic acid was incorporated and their time-dependent release profile was obtained by HPLC. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14341948
Volume :
2012
Issue :
32
Database :
Complementary Index
Journal :
European Journal of Inorganic Chemistry
Publication Type :
Academic Journal
Accession number :
83167416
Full Text :
https://doi.org/10.1002/ejic.201200583