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Bursting as a source of non-linear determinism in the firing patterns of nigral dopamine neurons.
- Source :
- European Journal of Neuroscience; Nov2012, Vol. 36 Issue 9, p3214-3223, 10p, 1 Diagram, 2 Charts, 5 Graphs
- Publication Year :
- 2012
-
Abstract
- Nigral dopamine (DA) neurons in vivo exhibit complex firing patterns consisting of tonic single-spikes and phasic bursts that encode information for certain types of reward-related learning and behavior. Non-linear dynamical analysis has previously demonstrated the presence of a non-linear deterministic structure in complex firing patterns of DA neurons, yet the origin of this non-linear determinism remains unknown. In this study, we hypothesized that bursting activity is the primary source of non-linear determinism in the firing patterns of DA neurons. To test this hypothesis, we investigated the dimension complexity of inter-spike interval data recorded in vivo from bursting and non-bursting DA neurons in the chloral hydrate-anesthetized rat substantia nigra. We found that bursting DA neurons exhibited non-linear determinism in their firing patterns, whereas non-bursting DA neurons showed truly stochastic firing patterns. Determinism was also detected in the isolated burst and inter-burst interval data extracted from firing patterns of bursting neurons. Moreover, less bursting DA neurons in halothane-anesthetized rats exhibited higher dimensional spiking dynamics than do more bursting DA neurons in chloral hydrate-anesthetized rats. These results strongly indicate that bursting activity is the main source of low-dimensional, non-linear determinism in the firing patterns of DA neurons. This finding furthermore suggests that bursts are the likely carriers of meaningful information in the firing activities of DA neurons. [ABSTRACT FROM AUTHOR]
- Subjects :
- SUBSTANTIA nigra
DOPAMINERGIC neurons
NEURONS
CHLORAL
ANESTHETICS
Subjects
Details
- Language :
- English
- ISSN :
- 0953816X
- Volume :
- 36
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- European Journal of Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 83148093
- Full Text :
- https://doi.org/10.1111/j.1460-9568.2012.08238.x