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Alteration of HLA-F and HLA I antigen expression in the tumor is associated with survival in patients with esophageal squamous cell carcinoma.

Alteration of HLA-F and HLA I antigen expression in the tumor is associated with survival in patients with esophageal squamous cell carcinoma.

Authors :
Zhang, X.
Lin, A.
Zhang, J.‐G.
Bao, W.‐G.
Xu, D.‐P.
Ruan, Y.‐Y.
Yan, W.‐H.
Source :
International Journal of Cancer; Jan2013, Vol. 132 Issue 1, p82-89, 8p
Publication Year :
2013

Abstract

Alteration of human leukocyte antigen (HLA) expression, such as decreased HLA I (HLA-A, -B and -C) antigens and elevated nonclassical HLA I antigens (HLA-E, -F and -G), was reported to have an unfavorable prognosis in various cancers. In our study, HLA-F expression in 105 primary esophageal squamous cell carcinoma (ESCC) lesions and 62 case-matched adjacent normal tissues, and HLA I antigens among 68 cases were analyzed by immunohistochemistry. Data revealed that HLA-F expression was observed in 58.1% (61/105) of the ESCC lesions and in 54.8% (34/62) of the normal esophageal tissues. Among the 62 case-matched samples, HLA-F expression (lesion vs. normal tissue) was upregulated, unchanged and downregulated in 13 (21.0%), 6 (9.6%) and 43 (69.4%) cases, respectively. Patients with HLA-F positive had a worse survival than those with HLA-F negative ( p = 0.040). Patients with upregulated HLA-F expression (lesion vs. normal tissue) had significantly worse survival than those with HLA-F unchanged and downregulated ( p = 0.010). Furthermore, decreased HLA I expression was observed in 41.2% (28/68) patients and was with worse prognosis in comparison to those with preserved HLA I expression ( p = 0.001). Multivariate analysis using Cox's proportional hazards model revealed that upregulated HLA-F expression ( p = 0.026) and downregulated HLA I expression ( p = 0.013) could be an independent unfavorable prognostic factor. In conclusion, our study provided the evidence that alteration of HLA I and HLA-F antigen expression was associated with survival in patients with ESCC. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00207136
Volume :
132
Issue :
1
Database :
Complementary Index
Journal :
International Journal of Cancer
Publication Type :
Academic Journal
Accession number :
82893688
Full Text :
https://doi.org/10.1002/ijc.27621