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SUMO, PTEN, and tumor suppression.

Authors :
Matunis, Michael J.
Guzzo, Catherine M.
Source :
Pigment Cell & Melanoma Research; Nov2012, Vol. 25 Issue 6, p718-720, 2p
Publication Year :
2012

Abstract

The article offers information on PTEN protein regarding tumor suppression. It mentions that PTEN protein is a lipid phosphatase that dephosphorylates phosphatidylinositol-3,4,5-triphosphate (PIP3). According to a study, PTEN is modified by the small ubiquitin-related modifier (SUMO). It includes that sumoylation facilitates cooperative binding of PTEN to the plasma membrane.

Subjects

Subjects :
PTEN protein
PHOSPHATASES
DEPHOSPHORYLATION
PHOSPHOINOSITIDES
COOPERATIVE binding (Biochemistry)
CELL membranes

Details

Language :
English
ISSN :
17551471
Volume :
25
Issue :
6
Database :
Complementary Index
Journal :
Pigment Cell & Melanoma Research
Publication Type :
Academic Journal
Accession number :
82605119
Full Text :
https://doi.org/10.1111/pcmr.12001
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