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Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers.
- Source :
- Brain: A Journal of Neurology; 2011, Vol. 134 Issue 1, p293-300, 8p
- Publication Year :
- 2011
-
Abstract
- 11Carbon-Pittsburgh compound B positron emission tomography studies have suggested early and prominent amyloid deposition in the striatum in presenilin 1 mutation carriers. This cross-sectional study examines the 11Carbon-Pittsburgh compound B positron emission tomography imaging profiles of presymptomatic and mildly affected (mini-mental state examination ≥20) carriers of seven presenilin 1 mutations, comparing them with groups of controls and symptomatic sporadic Alzheimer’s disease cases. Parametric ratio images representing 11Carbon-Pittsburgh compound B retention from 60 to 90 min were created using the pons as a reference region and nine regions of interest were studied. We confirmed that increased amyloid load may be detected in presymptomatic presenilin 1 mutation carriers with 11Carbon-Pittsburgh compound B positron emission tomography and that the pattern of retention is heterogeneous. Comparison of presenilin 1 and sporadic Alzheimer’s disease groups revealed significantly greater thalamic retention in the presenilin 1 group and significantly greater frontotemporal retention in the sporadic Alzheimer’s disease group. A few individuals with presenilin 1 mutations showed increased cerebellar 11Carbon-Pittsburgh compound B retention suggesting that this region may not be as suitable a reference region in familial Alzheimer’s disease. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00068950
- Volume :
- 134
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Brain: A Journal of Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 80127389
- Full Text :
- https://doi.org/10.1093/brain/awq310