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Chronic cardiac denervation affects the speed of coronary vascular regulation.
- Source :
- Cardiovascular Research; Nov1999, Vol. 44 Issue 3, p615-622, 8p
- Publication Year :
- 1999
-
Abstract
- Objective: We tested the hypothesis that the rate of adaptation of coronary metabolic vasodilatation and autoregulation is modulated by the cardiac nerves. Methods: Anaesthetised dogs (seven innervated (control) and seven with denervated hearts) were subjected to controlled pressure perfusion of the left main coronary artery. Heart rate was controlled by pacing. Results: The steady state autoregulation curves and metabolic regulation curves were similar in the two groups. A sudden increase or decrease in heart rate was associated with a faster response (22% shorter half-times) in the innervated than the denervated dogs (P<0.001). A sudden increase or decrease in coronary arterial perfusion pressure was associated with a slower response (24% longer half-times) in the innervated than the denervated hearts (P<0.005). Conclusions: We conclude that the speed of response to metabolic and perfusion pressure changes is partly mediated by cardio-cardiac reflexes. Reflex coronary vasodilatation appears to reinforce the metabolic vasodilatation of a heart rate increase and oppose the vasoconstriction in response to increased perfusion pressure. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00086363
- Volume :
- 44
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Cardiovascular Research
- Publication Type :
- Academic Journal
- Accession number :
- 80127235
- Full Text :
- https://doi.org/10.1016/S0008-6363(99)00257-6