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Does sublingual 17β-oestradiol have any effects on exercise capacity and myocardial ischaemia in post-menopausal women with stable coronary artery disease?
- Source :
- European Heart Journal; 1998, Vol. 19 Issue 7, p1019-1026, 8p
- Publication Year :
- 1998
-
Abstract
- Background A variety of vascular effects have been ascribed to 17β-oestradiol. These effects may partially explain the reduced incidence of cardiovascular disease found in post-menopausal women on oestrogen replacement therapy. Objectives To evaluate the effects of 2mg sublingual 17β-oestradiol on exercise capacity, exercise-induced myocardial ischaemia and circulating levels of endothelin-1 in post-menopausal women with stable coronary artery disease. Methods Twelve post-menopausal women, mean age 61 (range 52–72) years, with angiographically verified significant coronary artery disease, were randomly assigned to 2mg of sublingual 17β-oestradiol, 2·5mg of buccal nitroglycerine and to placebo in a double-blind cross-over study design with at least 2 days between each of the study arms. Antianginal medications, with the exception of beta-blockers, were discontinued before investigation. All study patients underwent a maximal bicycle exercise test 30min after drug intake. Blood was withdrawn immediately before and up to 8h after medication for analyses of circulating levels of oestradiol and endothelin-1. Results The mean serum levels of oestradiol increased from a control level of 72±28pmol.l−1to 3557± 1631pmol.l−1after 30min and to 5028±3971pmol.l−1after 60min with a gradual decline thereafter. Sublingual 17β-oestradiol did not induce any improvement in exercise duration when compared with nitroglycerin and placebo (500±112s, 505±107s, 498±157s), and did not influence time to onset of ST-segment depression (358±89s, 436±93s, 384±116s). The plasma levels of endothelin-1 did not change after administration of 17β-oestradiol, nitroglycerin or placebo. Conclusions No effects on exercise capacity, exercise-induced acute ischaemia, or plasma levels of endothelin-1 were found after a single dose of 2mg 17β-oestradiol in post-menopausal women with documented coronary artery disease. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 0195668X
- Volume :
- 19
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- European Heart Journal
- Publication Type :
- Academic Journal
- Accession number :
- 80088860
- Full Text :
- https://doi.org/10.1053/euhj.1998.0975