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Does sublingual 17β-oestradiol have any effects on exercise capacity and myocardial ischaemia in post-menopausal women with stable coronary artery disease?

Authors :
Al-Khalili, F
Landgren, B.-M
Eksborg, S
Franco-Cereceda, A
Schenck-Gustafsson, K
Source :
European Heart Journal; 1998, Vol. 19 Issue 7, p1019-1026, 8p
Publication Year :
1998

Abstract

Background A variety of vascular effects have been ascribed to 17β-oestradiol. These effects may partially explain the reduced incidence of cardiovascular disease found in post-menopausal women on oestrogen replacement therapy. Objectives To evaluate the effects of 2mg sublingual 17β-oestradiol on exercise capacity, exercise-induced myocardial ischaemia and circulating levels of endothelin-1 in post-menopausal women with stable coronary artery disease. Methods Twelve post-menopausal women, mean age 61 (range 52–72) years, with angiographically verified significant coronary artery disease, were randomly assigned to 2mg of sublingual 17β-oestradiol, 2·5mg of buccal nitroglycerine and to placebo in a double-blind cross-over study design with at least 2 days between each of the study arms. Antianginal medications, with the exception of beta-blockers, were discontinued before investigation. All study patients underwent a maximal bicycle exercise test 30min after drug intake. Blood was withdrawn immediately before and up to 8h after medication for analyses of circulating levels of oestradiol and endothelin-1. Results The mean serum levels of oestradiol increased from a control level of 72±28pmol.l−1to 3557± 1631pmol.l−1after 30min and to 5028±3971pmol.l−1after 60min with a gradual decline thereafter. Sublingual 17β-oestradiol did not induce any improvement in exercise duration when compared with nitroglycerin and placebo (500±112s, 505±107s, 498±157s), and did not influence time to onset of ST-segment depression (358±89s, 436±93s, 384±116s). The plasma levels of endothelin-1 did not change after administration of 17β-oestradiol, nitroglycerin or placebo. Conclusions No effects on exercise capacity, exercise-induced acute ischaemia, or plasma levels of endothelin-1 were found after a single dose of 2mg 17β-oestradiol in post-menopausal women with documented coronary artery disease. [ABSTRACT FROM PUBLISHER]

Details

Language :
English
ISSN :
0195668X
Volume :
19
Issue :
7
Database :
Complementary Index
Journal :
European Heart Journal
Publication Type :
Academic Journal
Accession number :
80088860
Full Text :
https://doi.org/10.1053/euhj.1998.0975