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Molecular Mechanisms of Oligodendrocyte Injury in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.

Authors :
Patel, Jilpa
Balabanov, Roumen
Source :
International Journal of Molecular Sciences; Aug2012, Vol. 13 Issue 8, p10647-10659, 13p, 3 Diagrams
Publication Year :
2012

Abstract

New evidence has emerged over the last decade indicating that oligodendrocyte injury in multiple sclerosis (MS) is not a single unified phenomenon but rather a spectrum of processes ranging from massive immune destruction to a subtle cell death in the absence of significant inflammation. Experimentally, protection of oligodendrocytes against inflammatory injury results in protection against experimental autoimmune encephalitis, the animal model of multiple sclerosis. In this review, we will discuss the molecular mechanisms regulating oligodendrocyte injury and inflammatory demyelination. We draw attention to the injurious role of IFN-γ signaling in oligodendrocytes and the pro-inflammatory effect of their death. In conclusion, studying the molecular mechanisms of oligodendrocyte injury is likely to provide new perspective on the pathogenesis of MS and a rationale for cell protective therapies. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16616596
Volume :
13
Issue :
8
Database :
Complementary Index
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
79564684
Full Text :
https://doi.org/10.3390/ijms130810647