The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation.

The article presents a study which examines the role of NACHT, LRR and PYD domains-containing protein (NALP)3 inflammasome in the release of interleukin-1(IL-1)beta from lipopolysaccharide (LPS)-primed microglia after exposure to a synthetic neurotoxic prion fragment (PrP106-126). The production of IL-1beta were assessed using enzyme-linked immunosorbent assay (ELISA). The involvement of NALP3 inflammasome in prion peptide-induced microglial activation is highlighted.