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LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; 7/17/2012, Vol. 109 Issue 29, p11770-11775, 6p
- Publication Year :
- 2012
-
Abstract
- Recognition of viral nucleic acids by pattern recognition receptors initiates type 1 IFN induction and Innate antiviral Immune response. Here we show that LSm14A, a member of the LSm family Involved in RNA processing in the processing bodies, binds to synthetic or viral RNA and DNA and mediates IRF3 activation and IFN-β Induction. Knockdown of LSm14A Inhibits cytosollc RNA- and DNA-trlgger type I IFN production and cellular antiviral response. Moreover, LSm14A Is essential for early-phase Induction of IFN-β after either RNA or DNA virus infection. We further found that LSm14A-medlated IFN-β Induction requires RIG-l-VISA or MITA after RNA or DNA virus Infection, respectively, and viral Infection causes translocation of LSm14A to peroxisomes, where RIG-l, VISA, and MITA are located. These findings suggest that LSm14A Is a sensor for both viral RNA and DNA and plays an Important role In Initiating IFN-ßβinduction In the early phase of viral Infection [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 109
- Issue :
- 29
- Database :
- Complementary Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 78150002
- Full Text :
- https://doi.org/10.1073/pnas.1203405109