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CONTRAST AGENT Gd- EOB- DTPA ( EOBĀ· PrimovistĀ®) FOR LOW-FIELD MAGNETIC RESONANCE IMAGING OF CANINE FOCAL LIVER LESIONS.
- Source :
- Veterinary Radiology & Ultrasound; Jul2012, Vol. 53 Issue 4, p371-380, 10p
- Publication Year :
- 2012
-
Abstract
- Contrast-enhanced magnetic resonance (MR) imaging with a new liver-specific contrast agent gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA; EOB·Primovist®) was studied in 14 normal beagles and 9 dogs with focal liver lesions. Gd-EOB-DTPA accumulates in normally functioning hepatocytes 20 min after injection. As with Gd-DTPA, it is also possible to perform a dynamic multiphasic examination of the liver with Gd-EOB-DTPA, including an arterial phase and a portal venous phase. First, a reliable protocol was developed and the appropriate timings for the dynamic study and the parenchymal phase in normal dogs using Gd-EOB-DTPA were determined. Second, the patterns of these images were evaluated in patient dogs with hepatic masses. The optimal time of arterial imaging was from 15 s after injection, and the optimal time for portal venous imaging was from 40 s after injection. Meanwhile, the optimal time to observe changes during the hepatobiliary phase was from 20 min after injection. In patient dogs, 11 lesions were diagnosed as malignant tumors; all were hypointense to the surrounding normal liver parenchyma during the hepatobiliary phase. Even with a low-field MR imaging unit, the sequences afforded images adequate to visualize the liver parenchyma and to detect tumors within an appropriate scan time. Contrast-enhanced MR imaging with Gd-EOB-DTPA provides good demarcation on low-field MR imaging for diagnosing canine focal liver lesions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10588183
- Volume :
- 53
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Veterinary Radiology & Ultrasound
- Publication Type :
- Academic Journal
- Accession number :
- 77908014
- Full Text :
- https://doi.org/10.1111/j.1740-8261.2011.01919.x