The MLL partial tandem duplication in adults aged 60 years and older with de novo cytogenetically normal acute myeloid leukemia.

Authors :: Whitman, S P
Caligiuri, M A
Maharry, K
Radmacher, M D
Kohlschmidt, J
Becker, H
Mrózek, K
Wu, Y-Z
Schwind, S
Metzeler, K H
Mendler, J H
Wen, J
Baer, M R
Powell, B L
Carter, T H
Kolitz, J E
Wetzler, M
Carroll, A J
Larson, R A
Marcucci, G
Source :: Leukemia (08876924); Jul2012, Vol. 26 Issue 7, p1713-1717, 5p, 2 Charts
Publication Year :: 2012
Abstract: The article explores the partial tandem duplication of the MLL gene (MLL-PTD) among adults aged 60 years old and above who have de novo cytogenitically normal acute myeloid leukemia (CN-AML). It examines blood or bone marrow of such patients who were treated on Cancer and Leukemia Group B. Also, it conducts genome-wide gene and microRNA-expression profiling, and assays to observe other molecular aberrations with prognostic significance in CN-AML.

Subjects :: CHROMOSOME duplication
ACUTE myeloid leukemia
BONE marrow diseases
GENE expression
GENOMES
GENETICS

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