Spontaneous Pulmonary Alveolar Proteinosis in Captive “Moustached Tamarins” (Saguinus mystax).

The article reports on seven cases resembling spontaneous pulmonary alveolar proteinosis (PAP) in nonhuman primates, the captive moustached tamarins (Saguinus mystax). It has found intra-alveolar accumulation of amorphous, amphophilic, periodic acid-Schiff-positive, finely granular to dense material in tamarin lung samples. Numerous, irregularly shaped osmiophilic lamellar bodies in type II pneumocytes were observed in the affected lungs through transmission electron microscopy.