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An X-ray crystallographic study of C-5 and C-6 substituted 1,3-dimethyl-6-aminouracil architectures.
- Source :
- Journal of Chemical Crystallography; Jul2012, Vol. 42 Issue 7, p711-720, 10p
- Publication Year :
- 2012
-
Abstract
- Uracil, one of the four RNA bases is a vital component in the complex processes of molecular genetics. The correct functioning of these processes depends on the types of bonds formed by uracil with the surroundings. This communication elaborates the versatile potential of 1,3-dimethyl-6-aminouracil (L) to form its 5-, 6- position substituted derivatives with different significant molecular packing behaviours. Presently, five crystals (L-L) have been synthesised and their crystallographic architectures are glimpsed in this paper. Analysis of crystal packing shows supra-molecular behaviours through hydrogen bonding and π-π interactions among the molecules in maintaining the integrity of the structures. The ligand 6,6'-diamino-1,1',3,3'-tetramethyl-5,5'-(benzylidene)bis[pyrimidine-2,4(1 H,3 H)-dione] was observed to be stabilised in a helical arrangement. Graphical Abstract: Versatile potential of 1, 3-dimethyl-6-aminouracil to form its 5-, 6- position substituted derivatives e.g. 6,6'-diamino-1,1',3,3'-tetramethyl-5,5'-(benzylidene)bis[pyrimidine-2,4(1 H,3 H)-dione] in a helical arrangement.[Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10741542
- Volume :
- 42
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of Chemical Crystallography
- Publication Type :
- Academic Journal
- Accession number :
- 77191072
- Full Text :
- https://doi.org/10.1007/s10870-012-0305-x