Proteomic Actions of Growth Hormone in the Nervous System.

The brain is an endocrine target site for pituitary growth hormone (GH) and an autocrine or paracrine target site for GH produced within nervous tissue. Growth hormone receptor (GHR)-mediated GH actions in the nervous system promote neural growth and differentiation, neuroprotection, neurotransmission, neuroendocrine function and behavior. Growth hormone signaling in the nervous system involves intracellular cascades and changes in gene transcription that often result in proteomic changes in the central and peripheral nervous systems. Neural GH actions mediated through changes in protein synthesis are summarized in this brief review. [ABSTRACT FROM AUTHOR]