NF-ΚB, IΚB Kinase and Interacting Signal Networks in Squamous Cell Carcinomas.

Nuclear factor-ΚB (NF-ΚB) transcription factors and the IΚB kinases (IKKs) that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-ΚB signaling also has a critical role in cancer development and progression. The canonical NF-ΚB pathway contributes to squamous cell carcinoma (SCC) development by interacting with other signaling pathways including tumor suppressive and oncogenic pathways in a tissue specific manner. In this chapter, we will summarize recent advances in the understanding of interconnections between NF-ΚB and IKKs, including IKKα which has NF-ΚB independent functions, in the context of SCC development and progression and as potential target for novel chemotherapy approaches. [ABSTRACT FROM AUTHOR]