Back to Search Start Over

Correlation of circulating dehydroepiandrosterone with activated protein C generation and carotid intima-media thickness in male patients with Type 2 diabetes.

Authors :
Suzuki, T.
Yano, Y.
Sakamoto, M.
Uemura, M.
Yasuma, T.
Onishi, Y.
Sasaki, R.
Matsumoto, K.
Hayashi, T.
Maruyama-Furuta, N.
Akatsuka, H.
Gabazza, E. C.
Sumida, Y.
Takei, Y.
Source :
Diabetic Medicine; Jul2012, Vol. 29 Issue 7, pe41-e46, 0p, 2 Charts, 1 Graph
Publication Year :
2012

Abstract

Diabet. Med. 29, e41-e46 (2012) Abstract Aims Dehydroepiandrosterone exerts a protective effect against cardiovascular diseases. However, the relationship of dehydroepiandrosterone with the anticoagulant factor activated protein C, generated by the thrombin-thrombomodulin complex on vascular endothelial cells, remains unknown. This study aimed at studying the relationship between dehydroepiandrosterone and activated protein C generation in patients with Type 2 diabetes. Methods Sixty-two male patients with Type 2 diabetes were enrolled in this study. Data obtained from 40 healthy male subjects were used as controls. The plasma levels of dehydroepiandrosterone, the activated protein C-protein C inhibitor complex, high-sensitivity C-reactive protein and monocyte chemoattractant protein-1 were measured by enzyme immunoassays. Carotid intima-media thickness was measured by ultrasonography. Results The plasma levels of dehydroepiandrosterone (5.15 ± 2.81 vs. 3.76 ± 2.16 ng/ml; P < 0.005) and the activated protein C-protein C inhibitor complex (1.90 ± 1.07 vs. 1.02 ± 0.51 ng/ml; P < 0.001) were significantly lower in patients with diabetes than in normal subjects. Univariate analysis showed a significant correlation of the plasma level of dehydroepiandrosterone with that of the activated protein C-protein C inhibitor complex ( r = 0.48, P < 0.001), high-sensitivity C-reactive protein ( r = −0.30, P < 0.05) and with the mean intima-media thickness ( r = −0.28, P < 0.05) in patients with diabetes. Stepwise multiple regression analysis showed that the plasma level of dehydroepiandrosterone is significantly correlated with the plasma levels of the activated protein C-protein C inhibitor complex ( F = 18.06) and high-sensitivity C-reactive protein ( F = 4.94). There was no correlation between the plasma levels of dehydroepiandrosterone and monocyte chemoattractant protein-1. Conclusions These results suggest that lower circulating levels of dehydroepiandrosterone are associated with decreased activated protein C generation and higher intima-media thickness in patients with Type 2 diabetes. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
07423071
Volume :
29
Issue :
7
Database :
Complementary Index
Journal :
Diabetic Medicine
Publication Type :
Academic Journal
Accession number :
76651789
Full Text :
https://doi.org/10.1111/j.1464-5491.2012.03573.x