The best of times, the worst of times for psychiatric disease.

The article offers information on psychiatric disease. It is attributable either to disordered circuitry or to disordered activity in brain circuitry. It mentions that genetic strategies converge, as a Genome study can only be turned into a confirmed gene by finding an excess of rare deleterious mutations in it, which means eventually searching for rare variants. With next-generation sequencing possiblity, DNA technology is mature to find structural variants and coding mutations.