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Combination Antiviral Therapy for Influenza: Predictions From Modeling of Human Infections.
- Source :
- Journal of Infectious Diseases; Jun2012, Vol. 205 Issue 11, p1642-1645, 4p
- Publication Year :
- 2012
-
Abstract
- Emergence of resistance is a major concern in influenza antiviral treatment and prophylaxis. Combination antiviral therapy might overcome this problem. Here, we estimate that all possible single mutants and a sizeable fraction of double mutants are generated during an uncomplicated influenza infection. While most of them may sustain a fitness cost, some variants may confer drug resistance and be selected during therapy. We argue that a triple combination regimen would markedly reduce the risk of antiviral resistance emergence in seasonal and pandemic influenza viruses, especially in seriously ill or immunocompromised hosts. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 205
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 75371059
- Full Text :
- https://doi.org/10.1093/infdis/jis265