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Role of the ubiquitin ligase Fbw7 in cancer progression.
- Source :
- Cancer & Metastasis Reviews; Mar2012, Vol. 31 Issue 1/2, p75-87, 13p
- Publication Year :
- 2012
-
Abstract
- Fbw7 is a member of F-box family proteins, which constitute one subunit of Skp1, Cul1, and F-box protein (SCF) ubiquitin ligase complex. SCF targets a set of well-known oncoproteins, including c-Myc, cyclin E, Notch, c-Jun, and Mcl-1, for ubiquitylation and degradation. Fbw7 provides specificity of the ubiquitylation of these substrate proteins via recognition of a consensus phosphorylated degron. Through regulation of several important proteins, Fbw7 controls diverse cellular processes, including cell-cycle progression, cell proliferation, differentiation, DNA damage response, maintenance of genomic stability, and neural cell stemness. As reduced Fbw7 expression level and loss-of-function mutations are found in a wide range of human cancers, Fbw7 is generally considered as a tumor suppressor. However, the exact mechanisms underlying Fbw7-induced tumor suppression is unclear. This review focuses on regulation network, biological functions, and genetic alteration of Fbw7 in connection with its role in cancer development. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01677659
- Volume :
- 31
- Issue :
- 1/2
- Database :
- Complementary Index
- Journal :
- Cancer & Metastasis Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 75163181
- Full Text :
- https://doi.org/10.1007/s10555-011-9330-z