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Changes in blood oxidative and antioxidant parameters in a group of Chinese patients with age-related macular degeneration.
- Source :
- Journal of Nutrition, Health & Aging; Mar2012, Vol. 16 Issue 3, p201-204, 4p
- Publication Year :
- 2012
-
Abstract
- Objective: To measure the oxidative and antioxidant biochemical parameters in the serum of Chinese patients with age-related macular degeneration (AMD) and in a similar age control group from the same area. Design: A case-control study. Participants: 56 AMD patients (21 early dry, 13 geographic atrophy and 22 wet form) and 34 normal subjects, similar for age and sex were studied. Measurements: Both groups completed a questionnaire about demographic characters and dieatry habit, and the levels of serum lipid peroxidation (malondialdehyde, MDA) and antioxidants parameters (vitamin C and E, the activities of superoxide dismutase-SOD, total antioxidant capacity - TAC) were determined. Results: There was a significantly higher frequency of daily intake of fruit and legumes in controls than in AMD patients. There was a significantly increased serum MDA levels and SOD activities, and significantly decreased serum vitamin C and total antioxidant capacity in AMD patients as compared to controls. The intensity of lipid peroxidation was higher with the progression of AMD. There was not difference in serum vitamin E levels between AMD patients and controls. Conclusion: Oxido-reduction disturbance may be involved in the pathogenesis of AMD. There is a significantly decreased antioxidant capacity in AMD patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANALYSIS of variance
ANTIOXIDANTS
ASIANS
CHI-squared test
FRUIT
INGESTION
LEGUMES
LIPID peroxidation (Biology)
OXIDATION-reduction reaction
QUESTIONNAIRES
RESEARCH funding
RETINAL degeneration
STATISTICS
SUPEROXIDE dismutase
VITAMIN C
VITAMIN E
MALONDIALDEHYDE
DATA analysis
CASE-control method
DATA analysis software
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 12797707
- Volume :
- 16
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Nutrition, Health & Aging
- Publication Type :
- Academic Journal
- Accession number :
- 74299827
- Full Text :
- https://doi.org/10.1007/s12603-011-0350-8